The binding of stromal interaction molecule 1 (STIM1) to ORAI calcium channels is critical for store-operated calcium entry (SOCE), a calcium influx pathway conserved among nearly all vertebrate cells. Although many major steps of this pathway are well understood, crucial details regarding the mechanism of STIM1 activation remain unclear. A study in this issue provides important new insights into the conformational changes that occur during STIM1 activation.
Change history
23 August 2013
In the version of this article initially published, "Lys251" was incorrectly substituted for "Leu251" in Figure 1 and in the text. The error has been corrected in the HTML and PDF versions of the article.
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Stefan Feske is a scientific cofounder and consultant of Calcimedica. Murali Prakriya declares no competing financial interests.
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Feske, S., Prakriya, M. Conformational dynamics of STIM1 activation. Nat Struct Mol Biol 20, 918–919 (2013). https://doi.org/10.1038/nsmb.2647
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DOI: https://doi.org/10.1038/nsmb.2647
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