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Releasing the brakes on a chromatin-remodeling enzyme

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Chromatin-remodeling enzymes use the energy from ATP hydrolysis to mobilize, disrupt or change the histone composition of nucleosomes, facilitating nearly every nuclear event. Two recent studies indicate that remodeling enzymes harness the power of an ancient constitutively active DNA translocase and that different remodeling enzymes may use specialized coupling domains that communicate the presence of nucleosomal epitopes to regulate translocase and remodeling activity.

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Figure 1: Four distinct families of chromatin-remodeling ATPases.
Figure 2: Model for regulation of ISWI ATPase activity and DNA translocation.

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Authors and Affiliations

  1. Benjamin J. Manning and Craig L. Peterson are at the Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.,

    Benjamin J. Manning & Craig L. Peterson

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  1. Benjamin J. Manning
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  2. Craig L. Peterson
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Correspondence to Craig L. Peterson.

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Manning, B., Peterson, C. Releasing the brakes on a chromatin-remodeling enzyme. Nat Struct Mol Biol 20, 5–7 (2013). https://doi.org/10.1038/nsmb.2482

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