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Intimate liaison with SR proteins brings exon junction complexes to unexpected places

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Exon junction complexes (EJCs) are deposited on mRNAs during splicing and are key regulators of the post-transcriptional fate of messenger ribonucleoprotein particles (mRNPs). Two recent papers reporting on the transcriptome-wide mapping of EJC-binding sites in human cells reveal an unexpected heterogeneity of EJC distribution on mRNAs and a tight network of EJC–SR protein interactions contributing to the formation of a higher-order, compacted mRNP structure.

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Figure 1: EJCs are differentially loaded onto mRNA, both at the canonical −24-nt positions as well as at noncanonical positions, and form stable megadalton-sized complexes by interacting with SR proteins and with themselves.

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  1. Oliver Mühlemann is at the Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.,

    Oliver Mühlemann

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Mühlemann, O. Intimate liaison with SR proteins brings exon junction complexes to unexpected places. Nat Struct Mol Biol 19, 1209–1211 (2012). https://doi.org/10.1038/nsmb.2454

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