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Writers and readers: deconvoluting the harmonic complexity of the histone code

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The application of time-resolved NMR spectroscopy to histone phosphorylation dynamics reveals mechanistic hierarchies within the active sites of the enzymes that regulate chromatin, thereby shedding new light on the complexity of the histone code.

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Figure 1: Intramolecular reaction hierarchies.

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Acknowledgements

Work in the author's laboratory is funded by US National Institutes of Health grant R01CA140522. S. Hanes is thanked for his helpful comments on this manuscript.

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  1. Michael S. Cosgrove is in the Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, New York, USA.,

    Michael S Cosgrove

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  1. Michael S Cosgrove
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Correspondence to Michael S Cosgrove.

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Cosgrove, M. Writers and readers: deconvoluting the harmonic complexity of the histone code. Nat Struct Mol Biol 19, 739–740 (2012). https://doi.org/10.1038/nsmb.2350

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