Skip to main content

Advertisement

SpringerLink
Log in

RAF-isotype switching: from B to C through PDE

  • News & Views
  • Published:

From Nature Structural & Molecular Biology

View current issue Submit your manuscript

A new study reveals that rewiring of MAPK signaling in cells expressing mutant RAS includes ERK-mediated BRAF inactivation and the concomitant activation of CRAF, partly through amplification by the phosphodiesterase 4 isoform.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: From BRAF to CRAF through PDE4.

Katie Vicari

References

  1. Dumaz, N. et al. Cancer Res. 66, 9483–9491 (2006).

    Article  CAS  Google Scholar 

  2. Marquette, A., André, J., Bagot, M., Bensussan, A. & Dumaz, N. Nat. Struct. Mol. Biol. 18, 584–591 (2011).

    Article  CAS  Google Scholar 

  3. Flaherty, K.T. et al. N. Engl. J. Med. 363, 809–819 (2010).

    Article  CAS  Google Scholar 

  4. Lee, J.T. et al. Pigment Cell Melanoma Res. 23, 820–827 (2010).

    Article  CAS  Google Scholar 

  5. Villanueva, J. et al. Cancer Cell 18, 683–695 (2010).

    Article  CAS  Google Scholar 

  6. Montagut, C. et al. Cancer Res. 68, 4853–4861 (2008).

    Article  CAS  Google Scholar 

  7. Nazarian, R. et al. Nature 468, 973–977 (2010).

    Article  CAS  Google Scholar 

  8. Kaplan, F.M., Shao, Y., Mayberry, M.M. & Aplin, A.E. Oncogene 30, 366–371 (2011).

    Article  CAS  Google Scholar 

  9. Heidorn, S.J. et al. Cell 140, 209–221 (2010).

    Article  CAS  Google Scholar 

  10. Conti, M. Mol. Endocrinol. 14, 1317–1327 (2000).

    Article  CAS  Google Scholar 

  11. Murata, T. et al. Anticancer Res. 30, 355–358 (2010).

    CAS  PubMed  Google Scholar 

  12. Narita, M. et al. Oncol. Rep. 17, 1133–1139 (2007).

    CAS  PubMed  Google Scholar 

  13. Shimizu, K. et al. Anticancer Res. 29, 1119–1122 (2009).

    CAS  PubMed  Google Scholar 

  14. Khaled, M., Levy, C. & Fisher, D.E. Genes Dev. 24, 2276–2281 (2010).

    Article  CAS  Google Scholar 

  15. Lee, H.J., Wall, B. & Chen, S. Pigment Cell Melanoma Res. 21, 415–428 (2008).

    Article  CAS  Google Scholar 

  16. Arozarena, I. et al. Cancer Cell 19, 45–57 (2011).

    Article  CAS  Google Scholar 

  17. Sensi, M. et al. Oncogene 25, 3357–3364 (2006).

    Article  CAS  Google Scholar 

  18. Tsao, H., Goel, V., Wu, H., Yang, G. & Haluska, F.G. J. Invest. Dermatol. 122, 337–341 (2004).

    Article  CAS  Google Scholar 

  19. Karreth, F.A., DeNicola, G.M., Winter, S.P. & Tuveson, D.A. Mol. Cell 36, 477–486 (2009).

    Article  CAS  Google Scholar 

  20. Kamata, T. et al. Cancer Res. 70, 8475–8486 (2010).

    Article  CAS  Google Scholar 

  21. Arnault, J.P. et al. J. Clin. Oncol. 27, e59–e61 (2009).

    Article  Google Scholar 

  22. Savai, R. et al. Expert Opin. Investig. Drugs 19, 117–131 (2010).

    Article  CAS  Google Scholar 

  23. Buscà, R. & Ballotti, R. Pigment Cell Res. 13, 60–69 (2000).

    Article  Google Scholar 

  24. Landi, M.T. et al. Science 313, 521–522 (2006).

    Article  CAS  Google Scholar 

  25. Hayward, N.K. Oncogene 22, 3053–3062 (2003).

    Article  CAS  Google Scholar 

  26. Ravipati, G., McClung, J.A., Aronow, W.S., Peterson, S.J. & Frishman, W.H. Cardiol. Rev. 15, 76–86 (2007).

    Article  Google Scholar 

  27. Montani, D. et al. Adv. Ther. 26, 813–825 (2009).

    Article  CAS  Google Scholar 

  28. Mitra, D., Robinson, K.C. & Fisher, D.E. Pigment Cell Melanoma Res. 24, 16–18 (2011).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Eric Lau and Ze'ev Ronai are in the Signal Transduction Program at the Sanford Burnham Medical Research Institute, La Jolla, California, USA.,

    Eric Lau & Ze'ev Ronai

Authors
  1. Eric Lau
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ze'ev Ronai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ze'ev Ronai.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lau, E., Ronai, Z. RAF-isotype switching: from B to C through PDE. Nat Struct Mol Biol 18, 517–518 (2011). https://doi.org/10.1038/nsmb.2063

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb.2063

  • Springer Nature America, Inc.

Search

Navigation