Combinatorial exploration of sequence space suggests five, but not three, kinds of amino acids can yield a foldable protein. Energy landscape ideas explain why such complexity might be needed.
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Wolynes, P. As simple as can be?. Nat Struct Mol Biol 4, 871–874 (1997). https://doi.org/10.1038/nsb1197-871
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DOI: https://doi.org/10.1038/nsb1197-871
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