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Observation of distinct nanosecond and microsecond protein folding events

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Two very fast phases in the incipient folding of apomyoglobin are assigned to the formation of the first local and global structural elements of the protein.

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References

  1. Creighton, T.E. ed., Protein Folding (Freeman, New York, 1992).

    Google Scholar 

  2. Jones, C.M. et al. A. Proc. Natl. Acad. Sci. USA 90, 11860–11864 (1993).

    Article  CAS  Google Scholar 

  3. Huang, G.S. & Oas, T.G. Proc. Natl. Acad. Sci. USA 92, 6878–6882 (1995).

    Article  CAS  Google Scholar 

  4. Phillips, C.M., Mitsutani, Y. & Hochstrasser, R.M. Proc. Natl. Acad. Sci. USA 92, 7292–7296 (1995).

    Article  CAS  Google Scholar 

  5. Nölting, B., Golbik, R. & Fersht, A.R. Proc. Natl. Acad. Sci USA 92, 10668–10672 (1995).

    Article  Google Scholar 

  6. Pascher, T., Chesnick, J.P., Winkler, J.R., & Gray, H.B. Science 271, 1558–1560 (1996).

    Article  CAS  Google Scholar 

  7. Williams, S. et al. Biochemistry 36, 691–698 (1996).

    Article  Google Scholar 

  8. Ballew, R.M., Sabelko, J. & Gruebele, M. Proc. Natl. Acad. Sci USA 93, 5759–5764 (1996).

    Article  CAS  Google Scholar 

  9. Jennings, P.A. & Wright, P.E. Science 262, 892–896 (1993).

    Article  CAS  Google Scholar 

  10. Kay, M.S. & Baldwin, R.L. Nature Struct. Biol. 3, 439–445 (1996).

    Article  CAS  Google Scholar 

  11. Nishii, I., Kataoka, M. & Goto, Y. J. Mol. Biol. 250, 223–238 (1995).

    Article  CAS  Google Scholar 

  12. Evans, S.V. & Brayer, G.D. J. Mol. Biol. 213, 885–897 (1990).

    Article  CAS  Google Scholar 

  13. Gast, K. et al. Eur. Biophys. J. 23, 297–305 (1994).

    Article  CAS  Google Scholar 

  14. Ballew, R.M., Sabelko, J. & Gruebele, M. Rev. Sci. Instrum. in the press.

  15. Hammes, G.G. & Roberts, P.B. J. Am. Chem. Soc. 91, 1812–1816 (1969).

    Article  CAS  Google Scholar 

  16. Poland, D. & Scheraga, H. J. Chem. Phys. 45, 2071–2080 (1966).

    Article  CAS  Google Scholar 

  17. Barrick, D. & Baldwin, R.L. Prot. Sci. 2, 869–876 (1993).

    Article  CAS  Google Scholar 

  18. Karplus, M. & Weaver, D.L. Prot. Sci. 3, 650–668 (1994).

    Article  CAS  Google Scholar 

  19. Panchenko, A.R., Luthey-Schulten, Z. & Wolynes, P.G. Proc. Natl. Acad. Science USA 93, 2008–2013 (1996).

    Article  CAS  Google Scholar 

  20. Bryngelson, J.D. & Wolynes, P.G. Proc. Natl. Acad. Sci. USA 84, 7524–7528 (1987).

    Article  CAS  Google Scholar 

  21. Hagen, S.J., Hofrichter, J., Szabo, A. & Eaton, W.A. Proc. Natl. Acad. Sci. USA in the press.

  22. Dill, K.A. et al. Prot. Sci. 4, 561–602 (1995).

    Article  CAS  Google Scholar 

  23. Sali, A., Shakhnovich, E. & Karplus, M. J. Mol. Biol. 235, 1614–1636 (1994).

    Article  CAS  Google Scholar 

  24. Sharp, K.A., Nicholls, A., Friedman, R. & Honig, B. Biochemistry 30, 9686–9697, (1991).

    Article  CAS  Google Scholar 

  25. Park, B. & Levitt, M. J. Mol. Biol. 258, 367–392 (1996).

    Article  CAS  Google Scholar 

  26. Hao, M.H. & Scheraga, H.A. J. Chem. Phys. 102, 1334–1338 (1995).

    Article  CAS  Google Scholar 

  27. Onuchic, J.N., Wolynes, P.G., Luthey-schulten, Z. & Socci, N.D. Proc. Natl. Acad. Sci. USA 92, 3626–2630 (1995).

    Article  CAS  Google Scholar 

  28. Wolynes, P.G., Onuchic, J.N., & Thirumalai, D. Science 267, 1619–1620 (1995).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Chemical Sciences and Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, IL, 61801, USA

    Richard Martin Ballew, Jobiah Sabelko & Martin Gruebele

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  1. Richard Martin Ballew
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  2. Jobiah Sabelko
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  3. Martin Gruebele
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Ballew, R., Sabelko, J. & Gruebele, M. Observation of distinct nanosecond and microsecond protein folding events. Nat Struct Mol Biol 3, 923–926 (1996). https://doi.org/10.1038/nsb1196-923

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  • DOI: https://doi.org/10.1038/nsb1196-923

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