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Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition

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Mutational studies of a serine proteinase inhibitor (serpin) reveal determinants of its structural rearrangements.

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Authors and Affiliations

  1. Department of Biochemistry, the University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75235-9038, USA

    H. Michael Tucker, James Mottonen, Elizabeth J. Goldsmith & Robert D. Gerard

  2. Department of Internal Medicine, the University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75235-9038, USA

    Robert D. Gerard

Authors
  1. H. Michael Tucker
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  2. James Mottonen
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  3. Elizabeth J. Goldsmith
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  4. Robert D. Gerard
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Tucker, H., Mottonen, J., Goldsmith, E. et al. Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition. Nat Struct Mol Biol 2, 442–445 (1995). https://doi.org/10.1038/nsb0695-442

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