The solution structure of the peptide nucleic acid (PNA)-DNA hybrid GCTATGTC·d(GACATAGC) reveals a new duplex conformation and demonstrates that PNA can conform to nucleic acid partners of different conformations.
References
Nielsen, P.E., Egholm M., Berg,, R.H. & Buchardt, O. Science 254, 1497–1500 (1991).
Egholm, M. et al. Nature 365, 566–568 (1993).
Noble, S.A. et al. Drug Development Res. 34, 184–195 (1995).
Demidov, V.V. et al Biochemical Pharmacology 48, 1310–1313 (1994).
Brown, S.C., Thompson S.A., Veal, J. M. & Davis, D. G. Science 265, 777–17805 (1994).
Betts, L, Josey J.A., Veal, J.M. & Jordan, S.R. Science 270, 1838–1841 (1995).
Leijon, M. et al. Biochemistry 33, 9820–9825 (1994).
Wüthrich, K. NMR of proteins and nucleic acids (Wiley, New York, 1986).
Almarsson, Ö., Bruice, T.C., Kerr, J. & Zuckermann, R.N. Proc. Natl. Acad. Sci. USA 90, 7518–7522 1993).
Saenger, W. Principles of nucleic acid structure (Springer, New York, 1984).
Christensen, L. et al. J. Peptide Sci. 3, 175–183 (1995).
Kettani, A., Kumar, R.A. & Patel, D.J. J. Mol. Biol. 24, 638–656 (1995).
Brünger, A.T. X-PLOR User Manual, version 3.1 (Yale University, New Haven, 1992).
Lavery, R. & Sklenar, H. J. Biomol. Struct. Dynam. 6, 655–667 (1989).
Nicholls, A., Sharp, K.A. & Honig, B. Proteins 11, 281–296 (1991).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Eriksson, M., Nielsen, P. Solution structure of a peptide nucleic acid–DNA duplex. Nat Struct Mol Biol 3, 410–413 (1996). https://doi.org/10.1038/nsb0596-410
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/nsb0596-410
- Springer Nature America, Inc.
This article is cited by
-
Artificial genetic polymers against human pathologies
Biology Direct (2022)
-
Peptide nucleic acid Hoogsteen strand linker design for major groove recognition of DNA thymine bases
Journal of Computer-Aided Molecular Design (2021)
-
Modular self-assembly of gamma-modified peptide nucleic acids in organic solvent mixtures
Nature Communications (2020)
-
Focus on PNA Flexibility and RNA Binding using Molecular Dynamics and Metadynamics
Scientific Reports (2017)
-
Structural characteristics of cyclopentane-modified peptide nucleic acids from molecular dynamics simulations
Structural Chemistry (2017)