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NMR structure of the 35-residue villin headpiece subdomain

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The NMR structure of an autonomously folding subdomain from villin headpiece is reported. It forms a novel three helix structure with the actin-binding residues arrayed on the C-terminal helix.

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Authors and Affiliations

  1. Department of Biophysics, Boston University School of Medicine, 80 East Concord St., Boston, Massachusetts, 02118, USA

    C. James McKnight

  2. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts, 02142, USA

    Paul T. Matsudaira & Peter S. Kim

  3. Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts, 02142, USA

    Peter S. Kim

Authors
  1. C. James McKnight
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  2. Paul T. Matsudaira
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  3. Peter S. Kim
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McKnight, C., Matsudaira, P. & Kim, P. NMR structure of the 35-residue villin headpiece subdomain. Nat Struct Mol Biol 4, 180–184 (1997). https://doi.org/10.1038/nsb0397-180

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