Two examples of protein structures that form knots raise questions about how protein knots should be defined and how such proteins fold.
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Mansfield, M. Fit to be tied. Nat Struct Mol Biol 4, 166–167 (1997). https://doi.org/10.1038/nsb0397-166
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DOI: https://doi.org/10.1038/nsb0397-166
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