Kinetic and spectroscopic evidence show that certain bZIP peptides favour a DMA binding mechanism in which monomers sequentially assemble into a dimer at their DMA target site.
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References
McKnight, S.L. Sci. Am. 264, 54–64 (1991).
Hurst, H.C. Protein Profile 2, 101–168 (1995).
Ellenberger, T.E., Brandl, C.J., Struhl, K. & Harrison, S.C. Cell 71, 1223–1237 (1992).
König, P. & Richmond, T.J. Mol. Biol. 233, 139–154 (1993).
Glover, J.N.M. & Harrison, S.C. Nature 373, 257–261 (1995).
Wendt, H., Baici, A. & Bosshard, H.R. J. Am. Chem. Soc. 116, 6973–6974 (1994).
Wendt, H., Berger, C., Baici, A., Thomas, R.M. & Bosshard, H.R. Biochemistry 34, 4097–4107 (1995).
Zitzewitz, J.A., Bilsel, O., Luo, J., Jones, B.E. & Matthews, C.R. Biochemistry 34, 12812–12819 (1995).
Metallo, S.J. & Schepartz, A. Chemistry & Biology 1, 143–151 (1994).
Park, C., Campbell, J.L. & Goddard, W.A. J. Am. Chem. Soc. 118, 4235–4239 (1996).
Hope, I. & Struhl, K. The EMBO Journal 6, 2781–2784 (1987).
Park, C., Campbell, J.L. & Goddard, W.A. J. Am. Chem. Soc. 117, 6287–6291 (1995).
Maekawa, T. et al. EMBO J. 8, 2023–2028 (1989).
Hinnebusch, A.G. & Fink, G.R. Proc. Natl. Acad. Sci. USA 80, 5374–5378 (1983).
Paolella, D.N., Palmer, C.R. & Schepartz, A. Science 264, 1130–1133 (1994).
Jencks, W.P. Catalysis in Chemistry and Enzymology (McGraw-Hill, New York, 1969).
Brown, B.M., Bowie, J.U. & Sauer, R.T. Biochemistry 29, 11189–11193 (1990).
Riggs, A.D., Bourgeois, S. & Cohn, M. J. Mol. Biol. 53, 401–417 (1970).
Hippel, P.H.v. & Berg, O.G. J. Biol. Chem. 264, 675–678 (1989).
Press, W.H., Flannery, B.P., Teukolsky, S.A. & Vetterling, W.T. Numerical Recipes: The Art of Scientific Computing (FORTRAN Version) (Cambridge University Press, Cambridge, U.K., 1989).
Weiss, M. Biochemistry 29, 8020–8024 (1990).
Palmer, C.R. et al. J. Am. Chem. Soc. 117, 8899–8907 (1995).
O'Neil, K.T., Hoess, R.H. & DeGrado, W.F. Science 249, 774–778 (1990).
Johnson, N.P., Lindstrom, J., Baase, W.A. & Hippel, P.H.v. Proc. Natl. Acad. Sci. USA 91, 4840–4844 (1994).
Getzoff, E.D. et al. Nature 306, 287–290 (1983).
Getzoff, E.D. et al. Nature 358, 347–351 (1992).
Thompson, K.S., Vinson, C.R. & Freire, E. Biochemistry 32, 5491–5496 (1993).
Mo, J., Holtzer, M.E. & Holtzer, A. Proc. Natl. Acad. Sci. USA 88, 916–920 (1991).
Schreiber, G. & Fersht, A.R. Nat. Struc. Biol. 3, 427–431 (1996).
Gerstle, J.T. & Fried, M.G. Electrophoresis 14, 725–731 (1993).
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Metallo, S., Schepartz, A. Certain bZIP peptides bind DMA sequentially as monomers and dimerize on the DMA. Nat Struct Mol Biol 4, 115–117 (1997). https://doi.org/10.1038/nsb0297-115
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DOI: https://doi.org/10.1038/nsb0297-115
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