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Second messenger control of chromatin remodeling

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Two recent studies show that some ATP-dependent chromatin remodeling complexes are subject to control by a surprising set of regulators — phosphoinositols. These studies extend earlier observations in mammalian cells and suggest that second messengers are regulators of chromatin remodeling.

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Figure 1: Small molecule control of chromatin remodeling in yeast.
Figure 2: Small molecule control of chromatin remodeling in mammals.

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Authors and Affiliations

  1. Department of Developmental Biology and the Department of Pathology, Stanford University, Stanford, 94305, California, USA

    Oliver J. Rando, Tian H. Chi & Gerald R. Crabtree

Authors
  1. Oliver J. Rando
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  2. Tian H. Chi
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  3. Gerald R. Crabtree
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Correspondence to Gerald R. Crabtree.

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Rando, O., Chi, T. & Crabtree, G. Second messenger control of chromatin remodeling. Nat Struct Mol Biol 10, 81–83 (2003). https://doi.org/10.1038/nsb0203-81

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