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Degrading liaisons: Siah structure revealed

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The structure of the substrate-binding domain of Siah provides insight into how this protein interacts with a diverse set of substrate proteins.

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Figure 1: Pathways involving Siah/Sina-family proteins.
Figure 2: The SBD of Siah is structurally similar to the TRAF domain of TRAF family proteins.
Figure 3: Surface representation of the Siah dimer and potential protein–protein interaction regions.

References

  1. Tang, A.H., Neufeld, T.P., Kwan, E. & Rubin, G.M. Cell 90, 459–467 (1997).

    Article  CAS  Google Scholar 

  2. Polekhina, G. et al. Nature Struct. Biol. 9, 68–75 (2002).

    Article  CAS  Google Scholar 

  3. Arch, R.H., Gedrich, R.W. & Thompson, C.B. Genes Dev. 12, 2821–2830 (1998).

    Article  CAS  Google Scholar 

  4. Ni, C.-Z. et al. Proc. Natl. Acad. Sci. USA 97, 10395–10399 (2000).

    Article  CAS  Google Scholar 

  5. Park, Y., Burkitt, V., Villa, A., Tong, L. & Wu, H. Nature 398, 533–538 (1999).

    Article  CAS  Google Scholar 

  6. McWhirter, S. et al. Proc. Natl. Acad. Sci. USA 96, 8408–8413 (1999).

    Article  CAS  Google Scholar 

  7. Deng, L. et al. Cell 103, 351–361 (2000).

    Article  CAS  Google Scholar 

  8. Relaix, F., Wei, X.J., Wu, X. & Sassoon, D.A. Nature Genet. 18, 287–291 (1998).

    Article  CAS  Google Scholar 

  9. Ye, H., Park, Y., Kreishman, M., Kieff, E. & Wu, H. Mol. Cell 4, 321–330 (1999).

    Article  CAS  Google Scholar 

  10. Park, Y.C. et al. Cell 101, 777–787 (2000).

    Article  CAS  Google Scholar 

  11. Matsuzawa, S., Takayama, S., Froesch, B.A., Zapata, J.M. & Reed, J.C. EMBO J. 17, 2736–2747 (1998).

    Article  CAS  Google Scholar 

  12. Matsuzawa, S. & Reed, J.C. Mol. Cell 7, 915–926 (2001).

    Article  CAS  Google Scholar 

  13. Liu, J. et al. Mol. Cell 7, 927–936 (2001).

    Article  CAS  Google Scholar 

  14. Hu, G., Zhang, S., Vidal, M., Baer, J.L. & Fearon, E.R. Genes Dev. 11, 2701–2714 (1997).

    Article  CAS  Google Scholar 

  15. Zhang, J., Guenther, M.G., Carthew, R.W. & Lazar, M.A. Genes Dev. 12, 1775–1780 (1998).

    Article  CAS  Google Scholar 

  16. Germani, A. et al. Oncogene 19, 5997–6006 (2000).

    Article  CAS  Google Scholar 

  17. Germani, A. et al. Mol. Cell. Biol. 19, 3798–3807 (1999).

    Article  CAS  Google Scholar 

  18. Relaix, F. et al. Proc. Natl. Acad. Sci. USA 97, 2105–2110 (2000).

    Article  CAS  Google Scholar 

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Acknowledgements

We thank C. Li for modeling and graphics, S. Matsuzawa for helpful discussions, and A. Sawyer for manuscript preparation.

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  1. the Burnham Institute, 10901 N.Torrey Pines Rd, La Jolla, 92037, California, USA

    John C. Reed & Kathryn R. Ely

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  1. John C. Reed
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  2. Kathryn R. Ely
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Correspondence to John C. Reed or Kathryn R. Ely.

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Reed, J., Ely, K. Degrading liaisons: Siah structure revealed. Nat Struct Mol Biol 9, 8–10 (2002). https://doi.org/10.1038/nsb0102-8

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