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Lessons from a bacterial cocaine esterase

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The structure of a bacterial cocaine esterase provides important new insight into the selectivity of the carboxylesterase enzyme family and the information gained from this work could lead to improved catalytic antibody-based therapies for cocaine toxicity.

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Figure 1: The chemical structure of cocaine as recognized by different carboxylesterases.

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Authors and Affiliations

  1. the Department of Biochemistry and Molecular Biology at Indiana University School of Medicine, Indianapolis, 46202, Indiana

    William F. Bosron & Thomas D. Hurley

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  1. William F. Bosron
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  2. Thomas D. Hurley
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Correspondence to William F. Bosron or Thomas D. Hurley.

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Bosron, W., Hurley, T. Lessons from a bacterial cocaine esterase. Nat Struct Mol Biol 9, 4–5 (2002). https://doi.org/10.1038/nsb0102-4

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