Studies using rodent and adult human prostate stem-progenitor cell models indicate that exposure to bisphenol A (BPA) during development increases susceptibility of the prostate gland to premalignancy later in life. A novel human organoid model has now been generated to study the effects of BPA on embryonic human prostate development.
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Acknowledgements
The authors' work is supported in part by grants from the US National Cancer Institute: R01CA015776 (S.-M.H.), R01CA112532 (S.-M.H.), R21CA156042 (N.N.C.T.); the US National Institute of Environmental Health Sciences: U01ES019480 (S.-M.H.), U01ES020988 (S.-M.H.), P30ES006096 (S.-M.H.), RC2ES018789 (S.-M.H.); and the US Department of Veterans Affairs I01BX000675 (S.-M.H.).
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Ho, SM., Tam, N. Organoid model shows effect of BPA on prostate development. Nat Rev Urol 12, 658–659 (2015). https://doi.org/10.1038/nrurol.2015.261
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DOI: https://doi.org/10.1038/nrurol.2015.261
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