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Prostate cancer

Intriguing data on inflammation and prostate cancer

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A new case–control study shows that inflammation on biopsy is associated with diagnosis of prostate cancer. We think a large population-based prospective study, specifically designed to investigate the longitudinal association between inflammation and subsequent onset of prostate cancer, is required to elucidate the true relationship between inflammation and prostate carcinogenesis.

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References

  1. Bostwick, D. G. et al. Human prostate cancer risk factors. Cancer 101 (Suppl.), 2371–2490 (2004).

    Article  CAS  Google Scholar 

  2. De Marzo, A. M. et al. Inflammation in prostate carcinogenesis. Nat. Rev. Cancer 7, 256–269 (2007).

    Article  CAS  Google Scholar 

  3. Corona, G. et al. Benign prostatic hyperplasia: a new metabolic disease of the aging male and its correlation with sexual dysfunctions. Int. J. Endocrinol. 2014, 329456 (2014).

    Article  Google Scholar 

  4. Vignozzi, L. et al. Benign prostatic hyperplasia: a new metabolic disease? J. Endocrinol. Invest. 37, 313–322 (2014).

    Article  CAS  Google Scholar 

  5. Gurel, B. et al. Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial. Cancer Epidemiol. Biomarkers Prev. 23, 847–856 (2014).

    Article  Google Scholar 

  6. Irani, J. et al. High-grade inflammation in prostate cancer as a prognostic factor for biochemical recurrence after radical prostatectomy. Pathologist Multi Center Study Group. Urology 54, 467–472 (1999).

    Article  CAS  Google Scholar 

  7. Davidsson, S. et al. Inflammation, focal atrophic lesions, and prostatic intraepithelial neoplasia with respect to risk of lethal prostate cancer. Cancer Epidemiol. Biomarkers Prev. 20, 2280–2287 (2011).

    Article  Google Scholar 

  8. Yli-Hemminki, T. H. et al. Histological inflammation and risk of subsequent prostate cancer among men with initially elevated serum prostate-specific antigen (PSA) concentration in the Finnish prostate cancer screening trial. BJU Int. 112, 735–741 (2013).

    Article  CAS  Google Scholar 

  9. Moreira, D. M. et al. Baseline prostate inflammation is associated with a reduced risk of prostate cancer in men undergoing repeat prostate biopsy: results from the REDUCE study. Cancer 120, 190–196 (2014).

    Article  CAS  Google Scholar 

  10. Grimes, D. A. & Schulz, K. F. False alarms and pseudo-epidemics: the limitations of observational epidemiology. Obstet. Gynecol. 120, 920–927 (2012).

    Article  Google Scholar 

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Correspondence to Mario Maggi.

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Vignozzi, L., Maggi, M. Intriguing data on inflammation and prostate cancer. Nat Rev Urol 11, 369–370 (2014). https://doi.org/10.1038/nrurol.2014.143

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