Skip to main content
SpringerLink
Log in

Sexual dysfunction

The potential of stem cell therapy for Peyronie disease

  • News & Views
  • Published:

From Nature Reviews Urology

View current issue Sign up to alerts

Stem-cell therapy has the potential to regenerate tissue and cure disease—an approach preferable to many current treatments that simply mitigate symptoms. Currently, there is no approved medical therapy for Peyronie disease; a recent study suggests stem cells could provide an intriguing treatment option for this difficult-to-treat tissue defect.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Castiglione, F. et al. Intratunical injection of human adipose tissue-derived stem cells prevents fibrosis and is associated with improved erectile function in a rat model of Peyronie's disease. Eur. Urol. doi:10.1016/j.eururo.2012.09.034.

  2. Chamberlain, G., Fox, J., Ashton, B. & Middleton, J. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25, 2739–2749 (2007).

    Article  CAS  Google Scholar 

  3. Lin, C. S., Lin, G. & Lue, T. F. Allogeneic and xenogeneic transplantation of adipose-derived stem cells in immunocompetent recipients without immunosuppressants. Stem Cells Dev. 21, 2770–2778 (2012).

    Article  Google Scholar 

  4. Lin, C. S. et al. Defining adipose tissue-derived stem cells in tissue and in culture. Histol. Histopathol. 25, 807–815 (2010).

    PubMed  Google Scholar 

  5. Huang, Y. C. et al. The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model. J. Sex. Med. 7, 1391–1400 (2010).

    Article  CAS  Google Scholar 

  6. Albersen, M. et al. Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J. Sex. Med. 7, 3331–3340 (2010).

    Article  Google Scholar 

  7. Zhang, H. et al. Adipose tissue-derived stem cells secrete CXCL5 cytokine with chemoattractant and angiogenic properties. Biochem. Biophys. Res. Commun. 402, 560–564 (2010).

    Article  CAS  Google Scholar 

  8. Gonzalez-Cadavid, N. F. & Rajfer, J. Experimental models of Peyronie's disease. Implications for new therapies. J. Sex. Med. 6, 303–313 (2009).

    Article  CAS  Google Scholar 

  9. Lin, G. et al. Pentoxifylline attenuates transforming growth factor-beta1-stimulated elastogenesis in human tunica albuginea-derived fibroblasts part 2: Interference in a TGF-beta1/Smad-dependent mechanism and downregulation of AAT1. J. Sex. Med. 7, 1787–1797 (2010).

    Article  CAS  Google Scholar 

  10. Albersen, M. et al. Multipotent stromal cell therapy for cavernous nerve injury-induced erectile dysfunction. J. Sex. Med. 9, 385–403 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, UC Davis Medical Center, 4860 Y Street, Suite 3500, Sacramento, 95817, CA, USA

    Alan W. Shindel

Authors
  1. Alan W. Shindel
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares an association with the speakers bureaux for Abbott and Endo and has received a past consultant fee for American Medical Systems.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Shindel, A. The potential of stem cell therapy for Peyronie disease. Nat Rev Urol 10, 8–9 (2013). https://doi.org/10.1038/nrurol.2012.221

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrurol.2012.221

  • Springer Nature Limited

Search

Navigation