Precise localization of prostate cancer is essential for the success of focal therapies. Despite suggestions that saturation biopsy might be useful in this regard, a new study implies it cannot accurately pinpoint prostate tumors. Research efforts would perhaps be better focused on identifying which patients require treatment for clinically localized prostate cancer in the first place.
References
Sanda, M. G. et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N. Engl. J. Med. 358, 1250–1261 (2008).
Bianco, F. J. Jr, Scardino, P. T. & Eastham, J. A. Radical prostatectomy: long-term cancer control and recovery of sexual and urinary function (“trifecta”). Urology 66 (Suppl. 5), 83–94 (2005).
Sartor, A. O. et al. Evaluating localized prostate cancer and identifying candidates for focal therapy. Urology 72 (Suppl. 6), S12–S24 (2008).
Shukla-Dave, A. et al. The utility of magnetic resonance imaging and spectroscopy for predicting insignificant prostate cancer: an initial analysis. BJU Int. 99, 786–793 (2007).
Taneja, S. S. & Mason, M. Candidate selection for prostate cancer focal therapy. J. Endourol. 24, 835–841 (2010).
Falzarano, S. M. et al. Can saturation biopsy predict prostate cancer localization in radical prostatectomy specimens: a correlative study and implications for focal therapy. Urology doi:10.1016/j.urology.2009.11.067.
Parker, C., Muston, D., Melia, J. & Dearnaley, D. A model of the natural history of screen-detected prostate cancer, and the effect of radical treatment on overall survival. Br. J. Cancer 94, 1361–1368 (2006).
Welch, H. G. & Black, W. C. Overdiagnosis in cancer. J. Natl Cancer Inst. 102, 605–613 (2010).
Andriole, G. L. et al. Mortality results from a randomized prostate-cancer screening trial. N. Engl J. Med. 360, 1310–1319 (2009).
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Sartor, O. Saturation biopsy does not accurately localize tumors. Nat Rev Urol 7, 479–480 (2010). https://doi.org/10.1038/nrurol.2010.139
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DOI: https://doi.org/10.1038/nrurol.2010.139
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