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Prostate cancer

Saturation biopsy does not accurately localize tumors

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Precise localization of prostate cancer is essential for the success of focal therapies. Despite suggestions that saturation biopsy might be useful in this regard, a new study implies it cannot accurately pinpoint prostate tumors. Research efforts would perhaps be better focused on identifying which patients require treatment for clinically localized prostate cancer in the first place.

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References

  1. Sanda, M. G. et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N. Engl. J. Med. 358, 1250–1261 (2008).

    Article  CAS  Google Scholar 

  2. Bianco, F. J. Jr, Scardino, P. T. & Eastham, J. A. Radical prostatectomy: long-term cancer control and recovery of sexual and urinary function (“trifecta”). Urology 66 (Suppl. 5), 83–94 (2005).

    Article  Google Scholar 

  3. Sartor, A. O. et al. Evaluating localized prostate cancer and identifying candidates for focal therapy. Urology 72 (Suppl. 6), S12–S24 (2008).

    Article  Google Scholar 

  4. Shukla-Dave, A. et al. The utility of magnetic resonance imaging and spectroscopy for predicting insignificant prostate cancer: an initial analysis. BJU Int. 99, 786–793 (2007).

    Article  CAS  Google Scholar 

  5. Taneja, S. S. & Mason, M. Candidate selection for prostate cancer focal therapy. J. Endourol. 24, 835–841 (2010).

    Article  Google Scholar 

  6. Falzarano, S. M. et al. Can saturation biopsy predict prostate cancer localization in radical prostatectomy specimens: a correlative study and implications for focal therapy. Urology doi:10.1016/j.urology.2009.11.067.

  7. Parker, C., Muston, D., Melia, J. & Dearnaley, D. A model of the natural history of screen-detected prostate cancer, and the effect of radical treatment on overall survival. Br. J. Cancer 94, 1361–1368 (2006).

    Article  CAS  Google Scholar 

  8. Welch, H. G. & Black, W. C. Overdiagnosis in cancer. J. Natl Cancer Inst. 102, 605–613 (2010).

    Article  Google Scholar 

  9. Andriole, G. L. et al. Mortality results from a randomized prostate-cancer screening trial. N. Engl J. Med. 360, 1310–1319 (2009).

    Article  CAS  Google Scholar 

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Sartor, O. Saturation biopsy does not accurately localize tumors. Nat Rev Urol 7, 479–480 (2010). https://doi.org/10.1038/nrurol.2010.139

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