Skip to main content

Advertisement

SpringerLink
Log in

Prostate Cancer

Regeneration of interest in the prostate

  • News & Views
  • Published:

From Nature Reviews Urology

View current issue Sign up to alerts

The growth of prostate acini from single cell implants in mice is a major breakthrough. Such results have important clinical implications, and will ultimately change the treatment paradigm for prostatic disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The single-cell transplantation procedure.
Figure 2: Multiple prostate epithelial cell types derived from a stem cell transplant.

References

  1. Leong, K. G., Wang, B. E., Johnson, L. & Gao, W. Q. Generation of a prostate from a single adult stem cell. Nature 456, 804–808 (2008).

    Article  CAS  PubMed  Google Scholar 

  2. Isaacs, J. T. & Coffey, D. S. Etiology and disease process of benign prostatic hyperplasia. Prostate Suppl. 2, 33–50 (1989).

    Article  CAS  PubMed  Google Scholar 

  3. Burger, P. E. et al. Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue. Proc. Natl Acad. Sci. USA 102, 7180–7185 (2005).

    Article  CAS  PubMed  Google Scholar 

  4. Collins, A. T., Habib, F. K., Maitland, N. J. & Neal, D. E. Identification and isolation of human prostate epithelial stem cells based on α2β1-integrin expression. J. Cell Sci. 114, 3865–3872 (2001).

    CAS  PubMed  Google Scholar 

  5. Richardson, G. D. et al. CD133, a novel marker for human prostatic epithelial stem cells. J. Cell Sci. 117, 3539–3545 (2004).

    Article  CAS  PubMed  Google Scholar 

  6. Niu, Y. et al. Targeting the stromal androgen receptor in primary prostate tumors at earlier stages. Proc. Natl Acad. Sci. USA 105, 12188–12193 (2008).

    Article  CAS  PubMed  Google Scholar 

  7. Van der Aa, F., Roskams, T., Blyweert, W. & De Ridder, D. Institial cells in the human prostate: a new therapeutic target. Prostate 56, 250–255 (2003).

    Article  PubMed  Google Scholar 

  8. Karbanová, J. et al. The stem cell marker CD133 (Prominin-1) is expressed in various human glandular epithelia. J. Histochem. Cytochem. 56, 977–993 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Grisanzio, C. & Signoretti, S. p63 in prostate biology and pathology. J. Cell. Biochem. 103, 1354–1368 (2008).

    Article  CAS  PubMed  Google Scholar 

  10. Maitland, N. J. & Collins, A. T. Prostate cancer stem cells: a new target for therapy. J. Clin. Oncol. 28, 2862–2870 (2008).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Yorkshire Cancer Research Cancer Research Unit, University of York, York, UK

    Anne T. Collins & Norman J. Maitland

Authors
  1. Anne T. Collins
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Norman J. Maitland
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anne T. Collins.

Ethics declarations

Competing interests

N. J. Maitland declared that he is a stockholder/director of Pro-Cure Therapeutics, which owns a patent portfolio relating to potential prostate drug targets. AT Collins and NJ Maitland have declared that they hold patents associated with the Pro-Cure Therapeutics portfolio.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Collins, A., Maitland, N. Regeneration of interest in the prostate. Nat Rev Urol 6, 184–186 (2009). https://doi.org/10.1038/nrurol.2009.48

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrurol.2009.48

  • Springer Nature Limited

This article is cited by

Search

Navigation