Tremendous progress has been made in the identification of rheumatoid arthritis (RA) risk factors in 2017. The results of epidemiological studies highlighted dietary and hormonal factors that are associated with slowing the transition from one preclinical phase of RA to another, potentially protecting individuals from developing RA.
This is a preview of subscription content, log in via an institution to check access.
References
Burgers, L. E. et al. Differences in the symptomatic phase preceding ACPA-positive and ACPA-negative RA: a longitudinal study in arthralgia during progression to clinical arthritis. Ann. Rheum. Dis. 76, 1751–1754 (2017).
Sparks, J. A. & Karlson, E. W. The roles of cigarette smoking and the lung in the transitions between phases of preclinical rheumatoid arthritis. Curr. Rheumatol. Rep. 18, 15 (2016).
Gan, R. W. et al. The association between omega-3 fatty acid biomarkers and inflammatory arthritis in an anti-citrullinated protein antibody positive population. Rheumatology (Oxford) 56, 2229–2236 (2017).
Hu, Y. et al. Long-term dietary quality and risk of developing rheumatoid arthritis in women. Ann. Rheum. Dis. 76, 1357–1364 (2017).
Orellana, C. et al. Oral contraceptives, breastfeeding and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study. Ann. Rheum. Dis. 76, 1845–1852 (2017).
Di Giuseppe, D. et al. Fish consumption and risk of rheumatoid arthritis: a dose-response meta-analysis. Arthritis Res. Ther. 16, 446 (2014).
Proudman, S. M. et al. Fish oil in recent onset rheumatoid arthritis: a randomised, double-blind controlled trial within algorithm-based drug use. Ann. Rheum. Dis. 74, 89–95 (2015).
Chiuve, S. E. et al. Alternative dietary indices both strongly predict risk of chronic disease. J. Nutr. 142, 1009–1018 (2012).
Bengtsson, C. et al. Association between menopausal factors and the risk of seronegative and seropositive rheumatoid arthritis: results from the Nurses' Health Studies. Arthritis Care Res. 69, 1676–1684 (2017).
Acknowledgements
The work of the authors is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), grant numbers K23 AR069688 and L30 AR066953 (to J.A.S.), R01 AR049880, R01 AR061362 and K24 AR066109 (to K.H.C.), as well as P30 AR070253 and P30 AR072577. The funding bodies had no role in the preparation of or decision to publish this manuscript. The content is the sole responsibility of the authors and does not necessarily represent the official views of the NIH.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Sparks, J., Costenbader, K. Protective dietary and hormonal factors brought to light. Nat Rev Rheumatol 14, 71–72 (2018). https://doi.org/10.1038/nrrheum.2017.216
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrrheum.2017.216
- Springer Nature Limited
This article is cited by
-
Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis
Arthritis Research & Therapy (2022)
-
Gut microbiota in children with juvenile idiopathic arthritis: characteristics, biomarker identification, and usefulness in clinical prediction
BMC Genomics (2020)