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Rheumatoid arthritis

Autoantibody testing to predict response to therapy in RA

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New research shows that an extended autoantibody repertoire is associated with adverse clinical outcomes in patients with rheumatoid arthritis. Testing for rheumatoid factor and antibodies against citrullinated proteins is now routine in the evaluation of patients with rheumatoid arthritis; should this testing be extended to include other classes of autoantibody?

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Figure 1: The breadth of the anti-modified protein antibody response determines the risk of relapse when tapering DMARD therapy in patients with rheumatoid arthritis.

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Acknowledgements

The work of L.A.T. and R.E.M.T. is supported by the Molecular Diagnostics in Rheumatoid Arthritis project (40-43600-98-14001); the Innovative Medicines Initiative Joint Undertaking funded project, Be The Cure (115142–2); the Dutch Arthritis Foundation and The Netherlands Organization for Scientific Research.

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  1. Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, Leiden, 2333, ZA, Netherlands

    Leendert A. Trouw & Rene E. M. Toes

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  1. Leendert A. Trouw
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  2. Rene E. M. Toes
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Correspondence to Leendert A. Trouw.

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Trouw, L., Toes, R. Autoantibody testing to predict response to therapy in RA. Nat Rev Rheumatol 12, 566–568 (2016). https://doi.org/10.1038/nrrheum.2016.151

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