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Inflammatory myopathies

Choosing the right biomarkers to predict ILD in myositis

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Interstitial lung disease is one of the most important causes of mortality in patients with polymyositis or dermatomyositis. Understanding the risk factors for development and progression of interstitial lung disease is crucial to improving clinical outcomes.

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References

  1. Hallowell, R. W., Ascherman, D. P. & Danoff, S. K. Pulmonary manifestations of polymyositis/dermatomyositis. Semin. Respir. Crit. Care Med. 35, 239–248 (2014).

    Article  Google Scholar 

  2. Zhang, L. et al. Factors associated with interstitial lung disease in patients with polymyositis and dermatomyositis: a systematic review and meta-analysis. PLoS ONE 11, e0155381 (2016).

    Article  Google Scholar 

  3. Fujisawa, T. et al. Prognostic factors for myositis-associated interstitial lung disease. PLoS ONE 9, e98824 (2014).

    Article  Google Scholar 

  4. Hamaguchi, Y. et al. Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multi-centre, cross-sectional study. Arch. Dermatol. 147, 391–398 (2011).

    Article  CAS  Google Scholar 

  5. Hamaguchi, Y. et al. Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome. PLoS ONE 8, e60442 (2013).

    Article  CAS  Google Scholar 

  6. Sato, S. et al. Clinical utility of an enzyme-linked immunosorbent assay for detecting anti-melanoma differentiation-associated gene 5 autoantibodies. PLoS ONE 11, e0154285 (2016).

    Article  Google Scholar 

  7. Chen, Z. S. et al. Utility of anti-melanoma differentiation-associated gene 5 antibody measurement in identifying patients with dermatomyositis and a high risk for developing rapidly progressive interstitial lung disease: a review of the literature and a meta-analysis. Arthritis Care Res. (Hoboken) 65, 1316–1324 (2013).

    Article  CAS  Google Scholar 

  8. Kawasumi, H., Gono, T., Kawaguchi, Y. & Yamanaka, H. Recent treatment of interstitial lung disease with idiopathic inflammatory myopathies. Clin. Med. Insights Circ. Respir. Pulm. Med. 9, 9–17 (2015).

    PubMed  PubMed Central  Google Scholar 

  9. Gono, T. et al. Anti-MDA5 antibody, ferritin and IL-18 are useful for the evaluation of response to treatment in interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis. Rheumatology (Oxford) 51, 1563–1570 (2012).

    Article  CAS  Google Scholar 

  10. Gono, T. et al. Cytokine profiles in polymyositis and dermatomyositis complicated by rapidly progressive or chronic interstitial lung disease. Rheumatology (Oxford) 53, 2196–2203 (2014).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Rheumatology, Jichi Medical University Saitama Medical Centre, 1–847 Amanuma-cho, Omiya-ku, Saitama-shi, 330–8503, Saitama-ken, Japan

    Takahisa Gono

  2. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113–8603, Japan

    Masataka Kuwana

Authors
  1. Takahisa Gono
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  2. Masataka Kuwana
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Correspondence to Masataka Kuwana.

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Competing interests

T.G. declares no competing interests. M.K. is an inventor on US patent application 13/059,444: 'Diagnosis method and diagnosis kit for dermatomyositis'.

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Gono, T., Kuwana, M. Choosing the right biomarkers to predict ILD in myositis. Nat Rev Rheumatol 12, 504–506 (2016). https://doi.org/10.1038/nrrheum.2016.120

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