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Musculoskeletal biology and bioengineering

A new in vivo stem cell model for regenerative rheumatology

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With advances in stem cell techniques for the bioengineering and regeneration of musculoskeletal tissues comes added complexity in our understanding of stem cell biology. How will the recent discovery of a novel stem cell subset, termed osteochondroreticular stem cells, contribute to progression in the field?

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Figure 1: HSCs are rare undifferentiated cells, primarily located in a bone marrow niche, that exhibit multipotency, with daughter progeny readily circulating and matured cells not regaining stem cell characteristics.

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Acknowledgements

Both authors' research is funded through WELMEC, a Centre of Excellence in Medical Engineering funded by the Wellcome Trust and the Engineering and Physical Sciences Research Council (EPSRC), under grant number WT 088908/Z/09/Z and the NIHR-funded Leeds Biomedical Research Unit.

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Authors and Affiliations

  1. The Mesenchymal Stem Cell Group, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Beckett Street, Leeds, LS9 7TF, UK

    Dennis McGonagle & Elena A. Jones

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  1. Dennis McGonagle
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  2. Elena A. Jones
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Correspondence to Dennis McGonagle.

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The authors declare no competing financial interests.

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McGonagle, D., Jones, E. A new in vivo stem cell model for regenerative rheumatology. Nat Rev Rheumatol 11, 200–201 (2015). https://doi.org/10.1038/nrrheum.2015.21

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