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Regenerative medicine

Selecting the right biological scaffold for tissue engineering

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From Nature Reviews Rheumatology

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Tissue engineers use mesenchymal stem cells (MSCs) and scaffolds for the regenerative treatment of injured or degenerated musculoskeletal tissues. As MSC interactions with state-of-the-art natural biological scaffolds are complex, the choice of a specific candidate for clinical applications based on interactions with MSCs in vitro, or even in vivo, is challenging.

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Acknowledgements

The authors are supported by the Bundesministerium für Bildung und Forschung (Grant: BCRT 1315848A).

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Authors and Affiliations

  1. Department of Rheumatology and Clinical Immunology, Tissue Engineering Laboratory and Berlin-Brandenburg Centre for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany

    Jochen Ringe & Michael Sittinger

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  1. Jochen Ringe
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  2. Michael Sittinger
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Correspondence to Jochen Ringe.

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Competing interests

M.S. declares that he is a shareholder of BioRetis and CellServe, and that he is a consultant for BioTissue Technologies. He is cofounder of the companies BioRetis, CellServe and TransTissue Technologies. J.R. declares no competing interests.

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Ringe, J., Sittinger, M. Selecting the right biological scaffold for tissue engineering. Nat Rev Rheumatol 10, 388–389 (2014). https://doi.org/10.1038/nrrheum.2014.79

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