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Oral or subcutaneous methotrexate for rheumatoid arthritis?

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Although methotrexate is the main therapy for rheumatoid arthritis, surprisingly little is known about the optimal route of administration; bioavailability of methotrexate has been shown to vary accordingly. In terms of delaying a switch to biologic therapy, is the subcutaneous route superior to oral methotrexate therapy?

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Change history

  • 17 September 2014

    In the original version of this article published online the competing interest statement for S.A. was missing. This error has now been corrected in the HTML and PDF versions of the article.

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Acknowledgements

The authors acknowledge the excellent secretarial assistance of S. Gillard.

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Authors and Affiliations

  1. King Fahd Hospital, Jeddah 21921, PO Box 176, Saudi Arabia

    Sabri Alsaeedi

  2. Mount Sinai Hospital, 60 Murray Street, Room 2-006, Toronto, M5T 3L9, ON, Canada

    Edward C. Keystone

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  1. Sabri Alsaeedi
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  2. Edward C. Keystone
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Correspondence to Edward C. Keystone.

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Competing interests

E.C.K. declares that he is a consultant for Antares Pharma. S.A. declares no competing interests.

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Alsaeedi, S., Keystone, E. Oral or subcutaneous methotrexate for rheumatoid arthritis?. Nat Rev Rheumatol 10, 578–579 (2014). https://doi.org/10.1038/nrrheum.2014.129

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