Osteoarthritis (OA) is a heterogeneous group of diseases with different pathogenesis in different joints. What effect do metabolic factors, inflammation and obesity have on OA in non-loadbearing structures? A new study reports that, in the absence of knee OA, systemic processes are important in the pathogenesis of hand OA.
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References
Visser, A. W. et al. The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study. Ann. Rheum Dis. http://dx.doi.org/10.1136/annrheumdis-2013-205012 (2014).
Jones, G., Ding, C., Scott, F., Glisson, M. & Cicuttini, F. Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females. Osteoarthritis Cartilage 12, 169–174 (2004).
Cicuttini, F. M., Jones, G., Forbes, A. & Wluka, A. E. Rate of cartilage loss at two years predicts subsequent total knee arthroplasty: a prospective study. Ann. Rheum. Dis. 63, 1124–1127 (2004).
Stannus, O. et al. Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthritis Cartilage 18, 1441–1447 (2010).
Jin, X. et al. Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2013-204494 (2013).
Roemer, F. W. et al. Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study. Ann. Rheum. Dis. 70, 1804–1809 (2011).
Ding, C. et al. Association between leptin, body composition, sex and knee cartilage morphology in older adults: the Tasmanian older adult cohort (TASOAC) study. Ann. Rheum. Dis. 67, 1256–1261 (2008).
Tanamas, S. et al. Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic review. Arthritis Rheum. 61, 459–467 (2009).
Carman, W. J., Sowers, M., Hawthorne, V. M. & Weissfeld, L. A. Obesity as a risk factor for osteoarthritis of the hand and wrist: a prospective study. Am. J. Epidemiol. 139, 119–129 (1994).
Massengale, M., Reichmann, W. M, Losina, E., Solomon, D. H. & Katz, J. N. The relationship between hand osteoarthritis and serum leptin concentration in participants of the Third National Health and Nutrition Examination Survey. Arthritis Res. Ther. 14, R132 (2012).
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A.E.W. is supported by an NHMRC Career Development Fellowship, Clinical level 2 (1063574).
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Cicuttini, F., Wluka, A. Is OA a mechanical or systemic disease?. Nat Rev Rheumatol 10, 515–516 (2014). https://doi.org/10.1038/nrrheum.2014.114
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DOI: https://doi.org/10.1038/nrrheum.2014.114
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