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Osteoarthritis

Metabolomic characterization of metabolic phenotypes in OA

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Increasing evidence implicates metabolic dysfunction in the development and progression of osteoarthritis (OA). Large-scale 'omics' studies, particularly metabolomics, have the potential to answer many questions relating to the pathogenesis of so-called 'metabolic OA' and other OA phenotypes, and could be key to the identification of novel biomarkers for these conditions.

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Figure 1: Development of analytical platforms for OA biomarker discovery and validation.

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Authors and Affiliations

  1. Rheumatology Division, ProteoRed/ISCIII Proteomic Group, INIBIC-Hospital Universitario A Coruña, As Xubias S/N, 15006-A, Coruña, Spain

    Francisco J. Blanco & Cristina Ruiz-Romero

Authors
  1. Francisco J. Blanco
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  2. Cristina Ruiz-Romero
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Correspondence to Francisco J. Blanco.

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The authors declare no competing financial interests.

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Blanco, F., Ruiz-Romero, C. Metabolomic characterization of metabolic phenotypes in OA. Nat Rev Rheumatol 8, 130–132 (2012). https://doi.org/10.1038/nrrheum.2012.11

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