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Regenerative medicine

Are calcium phosphate ceramics 'smart' biomaterials?

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Autologous bone grafts are the 'gold standard' repair strategy for large defects of bone, but a growing body of evidence suggests that synthetic biomaterials designed to have osteoinductive properties could provide an alternative approach.

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Authors and Affiliations

  1. Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, 30332-0363, GA, USA

    Barbara D. Boyan & Zvi Schwartz

Authors
  1. Barbara D. Boyan
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  2. Zvi Schwartz
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Correspondence to Barbara D. Boyan.

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Competing interests

B. D. Boyan and Z. Schwartz have received funding from the Musculoskeletal Transplant Foundation to study carriers for demineralized bone matrix, a grant from the NIH to support research on microstructured biomaterials and differentiation of osteoblasts and mesenchymal stem cells, and a grant from the US Department of Defense to develop technologies for stem cell delivery. B. D. Boyan has an issued US Patent for a method of making hydrogel implants (US Patent 7,682,540), and B. D. Boyan and Z. Schwartz have filed a provisional patent with the US Patent and Trademark Office for novel methods of applying nanotexture to metal implant. B. D. Boyan has served as a consultant for ApaTech, Exactech, and Spinology, in the development of synthetic bone graft substitutes.

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Boyan, B., Schwartz, Z. Are calcium phosphate ceramics 'smart' biomaterials?. Nat Rev Rheumatol 7, 8–9 (2011). https://doi.org/10.1038/nrrheum.2010.210

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