Several lines of evidence both from experimental models and from clinical studies reveal that TNF-like ligand 1A (TL1A) and its interaction with death receptor 3 (DR3) is critically involved in the pathogenesis of rheumatoid arthritis and other autoimmune diseases.
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References
Zhang, J. et al. Role of TL1A in the pathogenesis of rheumatoid arthritis. J. Immunol. 183, 5350–5357 (2009).
Bull, M. J. et al. The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis. J. Exp. Med. 205, 2457–2464 (2008).
Bamias, G. et al. Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis. Clin. Immunol. 129, 249–255 (2008).
Cassatella, M. A. et al. Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis. J. Immunol. 178, 7325–7333 (2007).
Migone, T. S. et al. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity 16, 479–492 (2002).
Bamias, G. et al. Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. J. Immunol. 171, 4868–4874 (2003).
Meylan, F. et al. The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases. Immunity 29, 79–89 (2008).
Pappu, B. P. et al. TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J. Exp. Med. 205, 1049–1062 (2008).
Osawa, K., Takami, N., Shiozawa, K., Hashiramoto, A. & Shiozawa, S. Death receptor 3 (DR3) gene duplication in a chromosome region 1p36.3: gene duplication is more prevalent in rheumatoid arthritis. Genes Immun. 5, 439–443 (2004).
Hayashi, S. et al. Decoy receptor 3 expressed in rheumatoid synovial fibroblasts protects the cells against Fas-induced apoptosis. Arthritis Rheum. 56, 1067–1075 (2007).
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The author is supported by grants from Institut National de le Santé et de la Recherche Médicale, Université Pierre et Marie Curie and Université Paris Descartes.
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Bayry, J. TL1A in the inflammatory network in autoimmune diseases. Nat Rev Rheumatol 6, 67–68 (2010). https://doi.org/10.1038/nrrheum.2009.263
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DOI: https://doi.org/10.1038/nrrheum.2009.263
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