A cross-sectional community-based study shows that strictly lobar cerebral microbleeds are associated with cognitive impairment, and might be a surrogate marker for early small-vessel injury. The anatomical distribution of cerebral microbleeds suggests that cerebral amyloid angiopathy (with or without Alzheimer disease) might have a key role in early cognitive impairment.
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Acknowledgements
The authors acknowledge funding support for work described in this article from a Grant-in-Aid for Scientific Research (C), JSPS KAKENHI (Grant Number 15k10364), and at UCLH/UCL, who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme.
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Y.Y has received research support from Novartis Pharma. D.J.W. declares honoraria from Bayer, and was UK chief investigator for a randomized controlled trial of ponezumab in cerebral amyloid angiopathy, sponsored by Pfizer.
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Yakushiji, Y., Werring, D. Lobar cerebral microbleeds signal early cognitive impairment. Nat Rev Neurol 12, 680–682 (2016). https://doi.org/10.1038/nrneurol.2016.179
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DOI: https://doi.org/10.1038/nrneurol.2016.179
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