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Multiple sclerosis

Linking disability and spinal cord imaging outcomes in MS

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In multiple sclerosis (MS), a clinicoradiological paradox exists whereby clinical and MRI measures show poor correlation. New findings suggest that quantitative imaging to assess microstructural changes in the spinal cords of patient with MS could overcome this paradox, and provide novel markers to monitor disease progression.

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Authors and Affiliations

  1. Division of Neuroscience, Neuroimaging Research Unit, Institute of Experimental Neurology, Scientific Institute and University Hospital San Raffaele, via Olgettina 60, Milan, 20132, Italy

    Massimo Filippi & Maria A. Rocca

Authors
  1. Massimo Filippi
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  2. Maria A. Rocca
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Correspondence to Massimo Filippi.

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Competing interests

M. Filippi serves on scientific advisory boards for Teva Pharmaceutical Industries Ltd. and Genmab A/S; has received funding for travel from Bayer Schering Pharma, Biogen Idec, Genmab A/S, Merck Serono, and Teva Pharmaceutical; serves as a consultant to Bayer Schering Pharma, Biogen Idec, Genmab A/S, Merck Serono, and Teva Pharmaceutical; serves on speakers' bureaus for Bayer Schering Pharma, Biogen Idec, Genmab A/S, Merck Serono, and Teva Pharmaceutical; and receives research support from Bayer Schering Pharma, Biogen Idec, Genmab A/S, Merck Serono, Teva Pharmaceutical. M. A. Rocca serves as a consultant to Bayer Schering Pharma; and has received speakers' fees from Biogen Idec.

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Filippi, M., Rocca, M. Linking disability and spinal cord imaging outcomes in MS. Nat Rev Neurol 9, 189–190 (2013). https://doi.org/10.1038/nrneurol.2013.40

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