Skip to main content
SpringerLink
Log in

Neuro-oncology

Anaplastic oligodendrogliomas—value of early chemotherapy

  • News & Views
  • Published:

From Nature Reviews Neurology

View current issue Sign up to alerts

Anaplastic oligodendroglial tumours are chemosensitive tumours—a fact that has been known for almost 25 years. The role and optimal timing of chemotherapy, however, has remained a subject of debate. Long-term results of two phase III trials now show that, in patients with 1p19q-codeleted tumours, early chemotherapy increases overall survival.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Cairncross, J. G. & Macdonald, D. R. Successful chemotherapy for recurrent malignant oligodendroglioma. Ann. Neurol. 23, 360–364 (1988).

    Article  CAS  Google Scholar 

  2. Cairncross, J. G. et al. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J. Natl Cancer Inst. 90, 1473–1479 (1998).

    Article  CAS  Google Scholar 

  3. Cairncross, G. et al. Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402. J. Clin. Oncol. http://dx.doi.org/10.1200/JCO.2012.43.2674.

  4. van den Bent, M. J. et al. Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC Brain Tumor Group Study 26951. J. Clin. Oncol. http://dx.doi.org/10.1200/JCO.2012.43.2229.

  5. Cairncross, G. et al. Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402. J. Clin. Oncol. 24, 2707–2714 (2006).

    Article  CAS  Google Scholar 

  6. van den Bent, M. J. et al. Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. J. Clin. Oncol. 24, 2715–2722 (2006).

    Article  CAS  Google Scholar 

  7. Lassman, A. B. et al. International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors. Neuro Oncol. 13, 649–659 (2011).

    Article  Google Scholar 

  8. Bettegowda, C. et al. Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science 333, 1453–1455 (2011).

    Article  CAS  Google Scholar 

  9. Jiao, Y. et al. Frequent ATRX, CIC, and FUBP1 mutations refine the classification of malignant gliomas. Oncotarget 3, 709–722 (2012).

    Article  Google Scholar 

  10. Sanson, M. et al. Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas. J. Clin. Oncol. 27, 4150–4154 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service de Neuro-oncologie, Hospices Civils de Lyon, Hôpital Neurologique, Bron, F-69677, France

    François Ducray

  2. Division Mazarin, Service de Neurologie 2, Groupe Hospitalier Pitié-Salpêtrière, APHP, Paris, 75013, France

    Ahmed Idbaih

Authors
  1. François Ducray
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ahmed Idbaih
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to François Ducray.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ducray, F., Idbaih, A. Anaplastic oligodendrogliomas—value of early chemotherapy. Nat Rev Neurol 9, 7–8 (2013). https://doi.org/10.1038/nrneurol.2012.248

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2012.248

  • Springer Nature Limited

This article is cited by

Search

Navigation