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Alzheimer disease

AD pathology—emerging subtypes or age-of-onset spectrum?

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A new cross-sectional study proposes three subtypes of Alzheimer disease: hippocampal-sparing, typical and limbic-predominant, associated with average lifespans of 72, 79 and 86 years, respectively. A longitudinal view suggests that age might be a major neuropathological determinant, with typical cases having younger onset and limbic-predominant cases having older onset.

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Authors and Affiliations

  1. Departments of Neurosciences and Pathology, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093-0624, CA, USA

    Eliezer Masliah & Lawrence A. Hansen

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  1. Eliezer Masliah
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  2. Lawrence A. Hansen
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Correspondence to Eliezer Masliah.

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The authors declare no competing financial interests.

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Masliah, E., Hansen, L. AD pathology—emerging subtypes or age-of-onset spectrum?. Nat Rev Neurol 8, 11–12 (2012). https://doi.org/10.1038/nrneurol.2011.205

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