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Neuro-oncology

Therapeutic benefits of reirradiation for recurrent brain tumors

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Malignant gliomas are aggressive tumors that often progress despite multimodality therapy. At recurrence, treatment approaches must balance the potential morbidity of a given therapy against the survival benefit that might be achieved. A new study reports that irradiation in this setting is well tolerated and could prolong survival.

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References

  1. Fogh, S. E. et al. Hypofractionated stereotactic radiation therapy: an effective therapy for recurrent high-grade gliomas. J. Clin. Oncol. 28, 3048–3053 (2010).

    Article  Google Scholar 

  2. Larson, D. A. et al. Gamma knife for glioma: selection factors and survival. Int. J. Radiat. Oncol. Biol. Phys. 36, 1045–1053 (1996).

    Article  CAS  Google Scholar 

  3. Kondziolka, D., Flickinger, J. C., Bissonette, D. J., Bozik, M. & Lunsford, L. D. Survival benefit of stereotactic radiosurgery for patients with malignant glial neoplasms. Neurosurgery 41, 776–783 (1997).

    Article  CAS  Google Scholar 

  4. Bernstein, M. et al. Brachytherapy for recurrent malignant astrocytoma. Int. J. Radiat. Oncol. Biol. Phys. 30, 1213–1217 (1994).

    Article  CAS  Google Scholar 

  5. Gabayan, A. J. et al. GliaSite brachtherapy for treatment of recurrent malignant gliomas: a retrospective multi-institutional analysis. Neurosurgery 58, 701–709 (2006).

    Article  Google Scholar 

  6. Shepherd, S. F. et al. Hypofractionated stereotactic radiotherapy in the management of recurrent glioma. Int. J. Radiat. Oncol. Biol. Phys. 37, 393–398 (1997).

    Article  CAS  Google Scholar 

  7. Fokas, E. et al. Hypofractionated stereotactic reirradiation of recurrent glioblastomas. Strahlenther. Onkol. 185, 235–240 (2009).

    Article  Google Scholar 

  8. Combs, S. E., Thilman, C., Edler, L., Debus, J. & Schulz-Ertner, D. Efficacy of fractionated stereotactic re-irradiation in recurrent gliomas: long-term results in 172 patients treated in a single institution. J. Clin. Oncol. 23, 8863–8869 (2005).

    Article  Google Scholar 

  9. Grosu, A. L. et al. Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 63, 511–519 (2005).

    Article  CAS  Google Scholar 

  10. Wen, P. Y. et al. Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J. Clin. Oncol. 28, 1963–1972 (2010).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, 15224, PA, USA

    Ian F. Pollack

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  1. Ian F. Pollack
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Pollack, I. Therapeutic benefits of reirradiation for recurrent brain tumors. Nat Rev Neurol 6, 533–535 (2010). https://doi.org/10.1038/nrneurol.2010.144

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