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Acute kidney injury

Acute kidney injury: still misunderstood and misdiagnosed

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New research supports the notion that pre-renal and intrinsic acute kidney injury are distinct molecular entities and hence different disease states despite similar increases in serum creatinine level. Pre-renal AKI induces protective molecular mechanisms whereas intrinsic AKI requires a 'second hit' that upregulates injury genes, and results in a persistent elevation of serum creatinine and kidney injury biomarkers.

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Acknowledgements

P.D. has received funding from the NIH (grant number P50DK096418).

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Authors and Affiliations

  1. Prasad Devarajan is at Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA.,

    Prasad Devarajan

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  1. Prasad Devarajan
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Correspondence to Prasad Devarajan.

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Competing interests

P.D. is a co-inventor on patents (7776824 and 7977110) related to NGAL as a biomarker of kidney injury, and declares licensing agreements with BioPorto Diagnostics and Abbott Diagnostics.

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Devarajan, P. Acute kidney injury: still misunderstood and misdiagnosed. Nat Rev Nephrol 13, 137–138 (2017). https://doi.org/10.1038/nrneph.2017.9

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