Skip to main content

Advertisement

SpringerLink
Log in

Biomarkers

Albuminuria — a marker of systemic microvascular function

  • News & Views
  • Published:

From Nature Reviews Nephrology

View current issue Sign up to alerts

A new study reports an independent association between albuminuria and skin capillary rarefaction in a population-based cohort. These findings suggest that as well as reflecting injury to the glomeruli — a highly specialized microvascular bed — albuminuria might be a surrogate marker of systemic microvascular and endothelial dysfunction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Martens, R. J. et al. Capillary rarefaction associates with albuminuria: The Maastricht Study. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2015111219 (2016).

  2. Stehouwer, C. D. & Smulders, Y. M. Microalbuminuria and risk for cardiovascular disease: analysis of potential mechanisms. J. Am. Soc. Nephrol. 17, 2106–2111 (2006).

    Article  CAS  Google Scholar 

  3. Serne, E. H. et al. Impaired skin capillary recruitment in essential hypertension is caused by both functional and structural capillary rarefaction. Hypertension 38, 238–242 (2001).

    Article  CAS  Google Scholar 

  4. Clausen, P., Jensen, J. S., Jensen, G., Borch-Johnsen, K. & Feldt-Rasmussen, B. Elevated urinary albumin excretion is associated with impaired arterial dilatory capacity in clinically healthy subjects. Circulation 103, 1869–1874 (2001).

    Article  CAS  Google Scholar 

  5. Nannipieri, M. et al. Increased transcapillary escape rate of albumin in microalbuminuric type II diabetic patients. Diabetes Care 18, 1–9 (1995).

    Article  CAS  Google Scholar 

  6. Nannipieri, M. et al. Transcapillary escape rate of albumin in type II diabetic patients. The relationship with microalbuminuria and hypertension. Diabetes Care 20, 1019–1026 (1997).

    Article  CAS  Google Scholar 

  7. Ehling, J. et al. Quantitative micro-computed tomography imaging of vascular dysfunction in progressive kidney diseases. J. Am. Soc. Nephrol. 27, 520–532 (2016).

    Article  CAS  Google Scholar 

  8. Triantafyllou, A. et al. Accumulation of microvascular target organ damage in newly diagnosed hypertensive patients. J. Am. Soc. Hypertens. 8, 542–549 (2014).

    Article  CAS  Google Scholar 

  9. Rabelink, T. J. & de Zeeuw, D. The glycocalyx — linking albuminuria with renal and cardiovascular disease. Nat. Rev. Nephrol. 11, 667–676 (2015).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The author's work is supported by financial research grants of the German Research Foundation (DFG; SFB/TRR 57), by the German Federal Ministry of Education and Research (BMBF 01GM1518A) and by the Else-Kröner Fressenius Stiftung (EKFS 2012_A216).

Author information

Authors and Affiliations

  1. Institute of Pathology & Division of Nephrology, RWTH University of Aachen, Pauwelsstrasse 30, Aachen, D-52074, Germany

    Peter Boor

Authors
  1. Peter Boor
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peter Boor.

Ethics declarations

Competing interests

The author declares no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Boor, P. Albuminuria — a marker of systemic microvascular function. Nat Rev Nephrol 12, 449–450 (2016). https://doi.org/10.1038/nrneph.2016.82

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2016.82

  • Springer Nature Limited

This article is cited by

Search

Navigation