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Transplantation

Utilizing the transcriptome to predict allograft fibrosis

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A new study has identified a gene set that might predict the development of renal allograft fibrosis. This finding represents a leap forward in transplant diagnostics, but further studies are needed to demonstrate that interventions based on this gene set can prevent fibrosis before it can be utilized to inform therapeutic decisions.

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Figure 1: Human renal allograft biopsy sample showing renal cortex with interstitial fibrosis and tubular atrophy.

References

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Authors and Affiliations

  1. Division of Transplant Surgery, Mayo Clinic, Arizona, USA

    Adyr Moss

  2. Division of Nephrology and Hypertension, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, 85044, Arizona, USA

    Bruce Kaplan

Authors
  1. Adyr Moss
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  2. Bruce Kaplan
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Correspondence to Adyr Moss.

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The authors declare no competing financial interests.

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Moss, A., Kaplan, B. Utilizing the transcriptome to predict allograft fibrosis. Nat Rev Nephrol 12, 652–653 (2016). https://doi.org/10.1038/nrneph.2016.134

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