Despite uncertainty in the KDIGO guidelines, new research has shown that they can accurately identify acute kidney injury in critically ill patients who have a high risk of mortality. Future refinements to AKI definitions will require biomarkers, and robust assessments in prospective studies.
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References
Luo, X. et al. A comparison of different diagnostic criteria of acute kidney injury in critically ill patients. Crit. Care 18, R144 (2014).
Bellomo, R. et al. Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit. Care 8, R204–R212 (2004).
Mehta, R. L. et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit. Care 11, R31 (2007).
Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int. Suppl. 2, 1–138 (2012).
Ricci, Z., Cruz, D. & Ronco, C. The RIFLE criteria and mortality in acute kidney injury: a systematic review. Kidney Int. 73, 538–546 (2008).
Chertow, G. M., Burdick, E., Honour, M., Bonventre, J. V. & Bates, D. W. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J. Am. Soc. Nephrol. 16, 3365–3370 (2005).
Levey, A. S., Levin, A. & Kellum, J. A. Definition and Classification of Kidney Diseases. Am. J. Kidney Dis. 61, 686–688 (2013).
Rodrigues, F. B. et al. Incidence and mortality of acute kidney injury after myocardial infarction: a comparison between KDIGO and RIFLE criteria. PLoS One 8, e69998 (2013).
Fujii, T., Uchino, S., Takinami, M. & Bellomo, R. Validation of the Kidney Disease: Improving Global Outcomes criteria for AKI and comparison of three criteria in hospitalized patients. Clin. J. Am. Soc. Nephrol. 9, 848–854 (2014).
Nisula, S. et al. Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study. Intensive Care Med. 39, 420–428 (2013).
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Jha, V., Kumar, V. Validating the KDIGO definition and staging—one step at a time. Nat Rev Nephrol 10, 550–551 (2014). https://doi.org/10.1038/nrneph.2014.160
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DOI: https://doi.org/10.1038/nrneph.2014.160
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