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Chronic kidney disease

Mesoamerican nephropathy—new clues to the cause

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An epidemic of chronic kidney disease of unknown aetiology has emerged in Central America and resulted in the highest rates of end-stage renal disease worldwide. New findings from the first renal biopsy study of patients with Mesoamerican nephropathy should help medical detectives to 'crack' the cause of this disease.

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References

  1. Wesseling, C. et al. (Eds) Mesoamerican nephropathy: report from the First International Research Workshop on MeN. (Central American Program for Work, Environment and Health, 2013).

    Google Scholar 

  2. Torres, C. et al. Decreased kidney function of unknown cause in Nicaragua: a community-based survey. Am. J. Kidney Dis. 55, 485–496 (2010).

    Article  Google Scholar 

  3. Peraza, S. et al. Decreased kidney function among agricultural workers in El Salvador. Am. J. Kidney Dis. 59, 531–540 (2012).

    Article  Google Scholar 

  4. O'Donnell, J. K. et al. Prevalence of and risk factors for chronic kidney disease in rural Nicaragua. Nephrol. Dial. Transplant. 26, 2798–2805 (2011).

    Article  Google Scholar 

  5. Wijkström, J. et al. Clinical and pathological characterization of Mesoamerican nephropathy: a new kidney disease in Central America. Am. J. Kidney Dis. http://dx.doi.org/10.1053/j.ajkd.2013.05.019.

  6. Cirillo, P. et al. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J. Am. Soc. Nephrol. 20, 545–553 (2009).

    Article  CAS  Google Scholar 

  7. Nakayama, T. et al. Dietary fructose causes tubulointerstitial injury in the normal rat kidney. Am. J. Physiol. Renal Physiol. 298, F712–F720 (2010).

    Article  CAS  Google Scholar 

  8. Grgic, I. et al. Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis. Kidney Int. 82, 172–183 (2012).

    Article  CAS  Google Scholar 

  9. Ren, Y., D'Ambrosio, M. A., Garvin, J. L., Wang, H. & Carretero, O. A. Possible mediators of connecting tubule glomerular feedback. Hypertension 53, 319–323 (2009).

    Article  CAS  Google Scholar 

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Acknowledgements

We thank Dr Ricardo Correa-Rotter for his valuable suggestions relating to this manuscript.

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Authors and Affiliations

  1. Division of Renal Diseases and Hypertension, University of Colorado, RC-2 Anschutz Medical Campus, Denver, 80045, CO, USA

    Richard J. Johnson

  2. Department of Nephrology, Laboratory of Renal Physiopathology, INC Ignacio Chávez, Juan Badiano 1, Mexico City, 14080, Mexico

    Laura G. Sánchez-Lozada

Authors
  1. Richard J. Johnson
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  2. Laura G. Sánchez-Lozada
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Correspondence to Richard J. Johnson.

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The authors declare no competing financial interests.

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Johnson, R., Sánchez-Lozada, L. Mesoamerican nephropathy—new clues to the cause. Nat Rev Nephrol 9, 560–561 (2013). https://doi.org/10.1038/nrneph.2013.174

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