The optimal dialysate bicarbonate concentration is one that prevents acidosis at the beginning of the next dialysis session while avoiding postdialysis alkalosis. Few studies have assessed the effect of different dialysate bicarbonate levels on patient outcomes, but Tentori et al. now report that high dialysate bicarbonate concentrations may contribute to adverse outcomes.
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Basile, C., Lomonte, C. A step towards optimal dialysate bicarbonate concentration. Nat Rev Nephrol 9, 565–566 (2013). https://doi.org/10.1038/nrneph.2013.167
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DOI: https://doi.org/10.1038/nrneph.2013.167
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