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Glomerular disease

ANCA-associated GN—to PLEX or not to PLEX?

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Plasma exchange (PLEX) is often included in the initial therapy of patients with antineutrophil cytoplasmic autoantibody-associated glomerulonephritis who present with severe kidney failure. However, new long-term follow-up data from the MEPEX trial suggest that PLEX may not improve survival in these patients.

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Authors and Affiliations

  1. Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, 622 West 168th Street, PH 4-124, New York, 10032, NY, USA

    Andrew S. Bomback & Gerald B. Appel

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  1. Andrew S. Bomback
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  2. Gerald B. Appel
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Correspondence to Gerald B. Appel.

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The authors declare no competing financial interests.

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Bomback, A., Appel, G. ANCA-associated GN—to PLEX or not to PLEX?. Nat Rev Nephrol 9, 436–438 (2013). https://doi.org/10.1038/nrneph.2013.126

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