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Assessment of kidney function

Estimating GFR in children

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In a new study, Schwartz and colleagues have investigated the best way to estimate glomerular filtration rate (GFR) in children. Having already improved GFR estimation with the use of creatinine-based equations, the investigators now propose a more precise method for cystatin C measurement. The precision of a GFR equation will strongly depend on the analytical precision of the biological variables included.

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References

  1. Schwartz, G. J. & Work, D. F. Measurement and estimation of GFR in children and adolescents. Clin. J. Am. Soc. Nephrol. 4, 1832–1843 (2009).

    Article  Google Scholar 

  2. Schwartz, G. J., Haycock, G. B., Edelmann, C. M. Jr & Spitzer, A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58, 259–263 (1976).

    CAS  PubMed  Google Scholar 

  3. Delanghe, J. R. How to estimate GFR in children. Nephrol. Dial. Transplant. 24, 714–716 (2009).

    Article  Google Scholar 

  4. Schwartz, G. J. et al. New equations to estimate GFR in children with CKD. J. Am. Soc. Nephrol. 20, 629–637 (2009).

    Article  Google Scholar 

  5. Piéroni, L. et al. A multicentric evaluation of IDMS-traceable creatinine enzymatic assays. Clin. Chim. Acta 412, 2070–2075 (2011).

    Article  Google Scholar 

  6. Schwartz, G. J. et al. Improved equations estimating GFR in children with chronic kidney disease using an immunonephelometric determination of cystatin C. Kidney Int. http://dx.doi.org/10.1038/ki.2012.169.

  7. Ng, D. K. et al. Universal GFR determination based on two time points during plasma iohexol disappearance. Kidney Int. 80, 423–430 (2011).

    Article  CAS  Google Scholar 

  8. Selistre, L. et al. GFR estimation in adolescents and young adults. J. Am. Soc. Nephrol. 23, 989–996 (2012).

    Article  CAS  Google Scholar 

  9. Staples, A., LeBlond, R., Watkins, S., Wong, C. & Brandt, J. Validation of the revised Schwartz estimating equation in a predominantly non-CKD population. Pediatr. Nephrol. 25, 2321–2326 (2010).

    Article  Google Scholar 

  10. Inker, L. A. et al. Expressing the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) cystatin C equations for estimating GFR with standardized serum cystatin C values. Am. J. Kidney Dis. 58, 682–684 (2011).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Nephrology, Dialysis, Hypertension, Transplantation, University of Liège, CHU Sart Tilman, Bâtiment B35, Liège, 4000, Belgium

    Pierre Delanaye

  2. Division of Nephrology, Charité University Medicine, Campus Virchow, Augustenburger Platz 1, Berlin, 13353, Germany

    Natalie Ebert

Authors
  1. Pierre Delanaye
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  2. Natalie Ebert
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Correspondence to Pierre Delanaye.

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The authors declare no competing financial interests.

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Delanaye, P., Ebert, N. Estimating GFR in children. Nat Rev Nephrol 8, 503–504 (2012). https://doi.org/10.1038/nrneph.2012.163

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