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A new specific test for idiopathic membranous nephropathy

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Circulating anti-phospholipase A2 receptor (PLA2R) antibodies have been identified as an immunological marker of disease activity in patients with idiopathic membranous nephropathy. A simple assay has been developed to detect anti-PLA2R antibodies in serum. Now, we can monitor the response to drugs and adapt therapy in daily clinical practice.

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Figure 1: Detection of circulating phospholipase A2 receptor antibodies using an indirect immunofluorescence test.

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Acknowledgements

The authors would like to acknowledge the support of grant ANR-07-Physio-016-01.

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Authors and Affiliations

  1. INSERM Unit 702 and Division of Nephrology, Tenon Hospital, 4 Rue de la Chine, Paris, 75020, France

    Hanna Debiec & Pierre Ronco

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  1. Hanna Debiec
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  2. Pierre Ronco
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Correspondence to Hanna Debiec.

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The authors declare no competing financial interests.

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Debiec, H., Ronco, P. A new specific test for idiopathic membranous nephropathy. Nat Rev Nephrol 7, 496–498 (2011). https://doi.org/10.1038/nrneph.2011.106

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