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Glomerular disease

ACEIs with or without corticosteroids in IgA nephropathy?

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A recent study demonstrated the superiority of prednisone plus ramipril in preventing progression of IgA nephropathy compared with ramipril alone in a group of patients at high risk of progressive renal damage. However, future clinical trials need to clarify whether more aggressive supportive therapy may match the benefits of immunosuppression.

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References

  1. Manno, C., Torres, D. D., Rossini, M., Pesce, F. & Schena, F. P. Randomized controlled clinical trial of corticosteroids plus ACE-inhibitors with long-term follow-up in proteinuric IgA nephropathy. Nephrol. Dial. Transplant. 24, 3694–3701 (2009).

    Article  CAS  Google Scholar 

  2. Lv, J. et al. Combination therapy of prednisone and ACE inhibitor versus ACE-inhibitor therapy alone in patients with IgA nephropathy: a randomized controlled trial. Am. J. Kidney Dis. 53, 26–32 (2009).

    Article  CAS  Google Scholar 

  3. Floege, J. & Eitner, F. Immune modulating therapy for IgA nephropathy: rationale and evidence. Semin. Nephrol. 28, 38–47 (2008).

    Article  CAS  Google Scholar 

  4. Pozzi, C. et al. Corticosteroids in IgA nephropathy: a randomised controlled trial. Lancet 353, 883–887 (1999).

    Article  CAS  Google Scholar 

  5. Praga, M., Gutiérrez, E., González, E., Morales, E. & Hernández, E. Treatment of IgA nephropathy with ACE inhibitors: a randomized and controlled trial. J. Am. Soc. Nephrol. 14, 1578–1583 (2003).

    Article  CAS  Google Scholar 

  6. Reich, H. N., Troyanov, S., Scholey, J. W. & Cattran, D. C. Remission of proteinuria improves prognosis in IgA nephropathy. J. Am. Soc. Nephrol. 18, 3177–3183 (2007).

    Article  CAS  Google Scholar 

  7. Eitner, F., Ackermann, D., Hilgers, R. D. & Floege, J. Supportive Versus Immunosuppressive Therapy of Progressive IgA nephropathy (STOP) IgAN trial: rationale and study protocol. J. Nephrol. 21, 284–289 (2008).

    CAS  PubMed  Google Scholar 

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Correspondence to Jürgen Floege.

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Eitner, F., Floege, J. ACEIs with or without corticosteroids in IgA nephropathy?. Nat Rev Nephrol 6, 252–254 (2010). https://doi.org/10.1038/nrneph.2010.31

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