Prerenal azotemia is a common occurrence in hospitalized patients and is generally easier to define in clinical practice than in clinical research. Monitoring the duration of acute kidney injury and biomarkers of kidney function might help distinguish prerenal azotemia from acute tubular necrosis in both clinical practice and research settings.
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References
Uchino, S., Bellomo, R., Bagshaw, S. M. & Goldsmith, D. Transient azotaemia is associated with a high risk of death in hospitalized patients. Nephrol. Dial. Transplant. 25, 1833–1839 (2010).
Thadhani, R., Pascual, M. & Bonventre, J. V. Acute renal failure. N. Engl. J. Med. 334, 1448–1460 (1996).
Klahr, S. & Miller, S. B. Acute oliguria. N. Engl. J. Med. 338, 671–675 (1998).
Bellomo, R. et al. Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the second international Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit. Care 8, R205–R212 (2004).
Mehta, R. L. et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit. Care 11, R31 (2007).
Bellomo, R., Bagshaw, S., Langenberg, C. & Ronco, C. Pre-renal azotemia: a flawed paradigm in critically ill septic patients? Contrib. Nephrol. 156, 1–9 (2007).
Brown, J. B., Kramer, R. S., Coca, S. G. & Parikh, C. R. Duration of acute kidney injury impacts long-term survival following cardiac surgery. Ann. Thorac. Surg. (in press).
Coca, S. G., King, J. T. Jr, Rosenthal, R. A., Perkal, M. F. & Parikh, C. R. The duration of postoperative acute kidney injury is an additional parameter predicting long-term survival in diabetic veterans. Kidney Int. doi: 10.1038/ki.2010.259.
Coca, S. G., Yalavarthy, R., Concato, J. & Parikh, C. R. Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review. Kidney Int. 73, 1008–1016 (2008).
Parikh, C. R., Lu, J. C., Coca, S. G. & Devarajan, P. Tubular proteinuria in acute kidney injury: a critical evaluation of current status and future promise. Ann. Clin. Biochem. 47, 301–312 (2010).
Acknowledgements
C. R. Parikh was supported by NIH grants UO1- DK82185 and RO1-HL85757. S. G. Coca was supported by the career development grant K23DK08013 from the NIH.
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Parikh, C., Coca, S. Defining prerenal azotemia in clinical practice and research. Nat Rev Nephrol 6, 641–642 (2010). https://doi.org/10.1038/nrneph.2010.128
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DOI: https://doi.org/10.1038/nrneph.2010.128
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