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Understanding drug resistance will improve the treatment of bacterial infections

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An improved understanding of the origins and spread of drug-resistant bacteria, as well as the identification of novel antimicrobial compounds and new drug combinations, will facilitate the development of better dosing regimens and novel strategies to manage drug resistance and prevent the dissemination of resistant bacteria.

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References

  1. Bevan, E. R., Jones, A. M. & Hawkey, P. M. Global epidemiology of CTX-M β-lactamases: temporal and geographical shifts in genotype. J. Antimicrob.Chemother. 72, 2145–2155 (2017).

    Article  CAS  Google Scholar 

  2. Basarab, G. S. et al. Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases. Sci. Rep. 5, 11827 (2015).

    Article  CAS  Google Scholar 

  3. Fisher, J. F. & Mobashery, S. Endless resistance. Endless antibiotics? Medchemcomm 7, 37–49 (2016).

    Article  CAS  Google Scholar 

  4. Richter, M. F. et al. Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature 545, 299–304 (2017).

    Article  CAS  Google Scholar 

  5. Llewelyn M. J. et al. The antibiotic course has had its day. BMJ 358, j3418 (2017).

    Article  Google Scholar 

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Correspondence to Laura J. V. Piddock.

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European Union Joint Programming Initiative on Antimicrobial Resistance

WHO

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Piddock, L. Understanding drug resistance will improve the treatment of bacterial infections. Nat Rev Microbiol 15, 639–640 (2017). https://doi.org/10.1038/nrmicro.2017.121

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