A ligase makes sense of DNA damage

DNA damage response

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Maréchal, A. et al. PRP19 transforms into a sensor of RPA–ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Mol. Cell http://dx.doi.org/10.1016/j.molcel.2013.11.002 (2013)

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Katharine H. Wrighton
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Wrighton, K. A ligase makes sense of DNA damage. Nat Rev Mol Cell Biol 15, 76–77 (2014). https://doi.org/10.1038/nrm3739

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