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Gut microbiota in 2017

Contribution of gut microbiota–host cooperation to drug efficacy

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2017 has witnessed key advances in knowledge about the metabolic capacities of the gut microbiota, enabling the progression of our understanding of the principles driving xenobiotic–bacteria–host interplay. This research paves the way for the long road towards personalized medicine and nutrition, which could be based on gut microbial metabolism.

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Figure 1: New metabolic pathways discovered in 2017 that underlie the xenobiotics–microbiota–host interplay.

Change history

  • 22 December 2017

    In the version of this article originally published online, the figure legend erroneously included part labels for the figure. This error has been corrected in the HTML, PDF and print versions of the article.

References

  1. Postler, T. S. & Ghosh, S. Understanding the holobiont: how microbial metabolites affect human health and shape the immune system. Cell Metab. 26, 110–130 (2017).

    Article  CAS  Google Scholar 

  2. Cohen, L. J. et al. Commensal bacteria make GPCR ligands that mimic human signalling molecules. Nature 549, 48–53 (2017).

    Article  CAS  Google Scholar 

  3. Guo, C. J. et al. Discovery of reactive microbiota-derived metabolites that inhibit host proteases. Cell 168, 517–526.e18 (2017).

    Article  CAS  Google Scholar 

  4. Spanogiannopoulos, P., Bess, E. N., Carmody, R. N. & Turnbaugh, P. J. The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism. Nat. Rev. Microbiol. 14, 273–287 (2016).

    Article  CAS  Google Scholar 

  5. Scott, T. A. et al. Host–microbe co-metabolism dictates cancer drug efficacy in C. elegans. Cell 169, 442–456.e18 (2017).

    Article  CAS  Google Scholar 

  6. Garcia-Gonzalez, A. P. et al. Bacterial metabolism affects the C. elegans response to cancer chemotherapeutics. Cell 169, 431–441.e8 (2017).

    Article  CAS  Google Scholar 

  7. Qin, J. et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59–65 (2010).

    Article  CAS  Google Scholar 

  8. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 486, 207–214 (2012).

  9. [No authors listed.] Data models to GO-FAIR. Nat. Genet. 49, 971 (2017).

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Authors and Affiliations

  1. Nathalie M. Delzenne and Laure B. Bindels are at Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Avenue E. Mounier, 73, B1.73.11, 1200 Brussels, Belgium.,

    Nathalie M. Delzenne & Laure B. Bindels

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  1. Nathalie M. Delzenne
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  2. Laure B. Bindels
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Correspondence to Nathalie M. Delzenne.

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The authors declare no competing financial interests.

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Delzenne, N., Bindels, L. Contribution of gut microbiota–host cooperation to drug efficacy. Nat Rev Gastroenterol Hepatol 15, 69–70 (2018). https://doi.org/10.1038/nrgastro.2017.170

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