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Viral hepatitis

HBV cure—can we pin our hopes on immunotherapy?

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From Nature Reviews Gastroenterology & Hepatology

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Therapeutic vaccines are considered to be able to reverse the dysfunctional immune state of chronic hepatitis B and thus hold the promise for HBV cure. Martin et al. developed a novel adenovirus-based therapeutic vaccine TG1050 and demonstrated its induction of long-lasting antiviral CD8+ T-cell immunity in mouse models of HBV persistence.

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Figure 1: Curing chronic hepatitis B.

References

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Authors and Affiliations

  1. Department of Microbiology, National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei, 10002, Taiwan

    Hung-Chih Yang

  2. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei, 10002, Taiwan

    Jia-Horng Kao

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  1. Hung-Chih Yang
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  2. Jia-Horng Kao
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Correspondence to Jia-Horng Kao.

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The authors declare no competing financial interests.

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Yang, HC., Kao, JH. HBV cure—can we pin our hopes on immunotherapy?. Nat Rev Gastroenterol Hepatol 12, 129–131 (2015). https://doi.org/10.1038/nrgastro.2015.8

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